Problems related to the safety and quality of drugs exist in many places around the world today, in developing and developed countries alike. Some incidents have ended in tragedy, often with children as the victims. They are caused by the use of drugs containing toxic substances or impurities, drugs whose claims have not been verified, drugs with unknown and severe adverse reactions, substandard preparations, or outright fake and counterfeit drugs. Effective drug regulation is required to ensure the safety, efficacy and quality of drugs, as well as the accuracy and appropriateness of the drug information available to the public. The prohibition of drugs through sumptuary legislation or religious law is a common means of attempting to prevent the recreational use of certain intoxicating substances.While some drugs are illegal to possess, many governments regulate the manufacture, distribution, marketing, sale and use of certain drugs, for instance through a prescription system.